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Pragmatic trials are those that are designed to inform the real-world practice of clinical. They are often described as a focus on the practical aspects of design, including the recruitment and consent process, as well as adherence and 프라그마틱 정품 확인법 the use routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and included participants from different geographical regions. This kind of heterogeneity, which is essential for pragmatic trials to be reliable and lessen the chance of bias, is also necessary. However excessive heterogeneity could cause problems with the design of the trial.
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The goal of pragmatic trials is to mimic real-life situations and achieve maximum credibility externally. They are usually commissioned by policymakers and practitioners to guide their decisions. They can be used to determine the cause-effect relationship of an intervention with its outcomes. They should not, however, be used to replace the need for explanation studies.
The concept of pragmatism is controversial and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm a physiological or clinical hypothesis, and pragmatic trials, which inform the policy and practice of. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool was designed to define the features of a pragmatic trial, including the recruitment process, the design and implementation of the intervention, and follow-up.
The number of pragmatic trials is growing. A recent Medline search using the keywords naturalistic and pragmatic, limited to randomized controlled trials (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to remember that the majority of studies were conducted in primary-care settings.
